Impact of Natural Genetic Variation on Gene Expression Dynamics

@inproceedings{Ackermann2013ImpactON,
  title={Impact of Natural Genetic Variation on Gene Expression Dynamics},
  author={Marit Ackermann and Weronika Sikora-Wohlfeld and Andreas Beyer},
  booktitle={PLoS genetics},
  year={2013}
}
DNA sequence variation causes changes in gene expression, which in turn has profound effects on cellular states. These variations affect tissue development and may ultimately lead to pathological phenotypes. A genetic locus containing a sequence variation that affects gene expression is called an "expression quantitative trait locus" (eQTL). Whereas the impact of cellular context on expression levels in general is well established, a lot less is known about the cell-state specificity of eQTL… CONTINUE READING
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