Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation.

@article{Krger2017ImpactOM,
  title={Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation.},
  author={Nicolaus M. Kr{\"o}ger and Victoria Panagiota and Anita Badbaran and Tatjana Zabelina and Ioanna Triviai and Michelle Maria Araujo Cruz and Rabia Shahswar and Francis Ayuketang Ayuk and Marten Gehlhaar and Christine Wolschke and Robin Bollin and Carolin Walter and Martin Dugas and Lutz Wiehlmann and Ulrich Lehmann and Christian Koenecke and Anuhar Chaturvedi and Haefaa Alchalby and Michael E. Stadler and M. Eder and Max Christopeit and Gudrun G{\"o}hring and Michael P Koenigsmann and Brigitte Schlegelberger and H. Kreipe and Arnold Ganser and Carol B. Stocking and Boris Fehse and Felicitas R Thol and Michael S. Heuser},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2017},
  volume={23 7},
  pages={
          1095-1101
        }
}
Molecular genetics may influence outcome for patients with myelofibrosis. To determine the impact of molecular genetics on outcome after allogeneic stem cell transplantation, we screened 169 patients with primary myelofibrosis (n = 110), post-essential thrombocythemia/polycythemia vera myelofibrosis (n = 46), and myelofibrosis in transformation (n = 13) for mutations in 16 frequently mutated genes. The most frequent mutation was JAK2V617F (n = 101), followed by ASXL1 (n = 49), calreticulin (n… CONTINUE READING
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