Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

@inproceedings{Denzler2016ImpactOM,
  title={Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression},
  author={R{\'e}my Denzler and Sean E. McGeary and Alexandra C. Title and Vikram Agarwal and David P. Bartel and Markus Stoffel},
  booktitle={Molecular cell},
  year={2016}
}
Expression changes of competing endogenous RNAs (ceRNAs) have been proposed to influence microRNA (miRNA) activity and thereby regulate other transcripts containing miRNA-binding sites. Here, we find that although miRNA levels define the extent of repression, they have little effect on the magnitude of the ceRNA expression change required to observe derepression. Canonical 6-nt sites, which typically mediate modest repression, can nonetheless compete for miRNA binding, with potency ∼20% of that… CONTINUE READING
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