Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL.

@article{Viswanathan2010ImpactOM,
  title={Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL.},
  author={Anand Viswanathan and Ophelia Godin and Eric Jouvent and Michael D O'Sullivan and Andreas Gschwendtner and Nils Peters and Marco Duering and J R Guichard and M Holtmannsp{\"o}tter and Carole Dufouil and Chahin Pachai and M T Bousser and Martin Dichgans and Hugues Chabriat},
  journal={Neurobiology of aging},
  year={2010},
  volume={31 9},
  pages={1629-36}
}
CADASIL is an arteriopathy caused by mutations of the Notch3 gene. White matter hyperintensities (WMH), lacunar lesions (LL), cerebral microhemorrhages (CM), brain atrophy and tissue microstructural changes are detected on MRI. Using an integrated multi-modal approach, we examined the relative impact of lesion burden and location of these MRI markers on cognitive impairment and disability. Multi-modal imaging was performed on 147 patients from a two-center cohort study. Volume of LL, WMH and… CONTINUE READING