Impact of Loading Phase, Initial Response and CFH Genotype on the Long-Term Outcome of Treatment for Neovascular Age-Related Macular Degeneration

@inproceedings{Menghini2012ImpactOL,
  title={Impact of Loading Phase, Initial Response and CFH Genotype on the Long-Term Outcome of Treatment for Neovascular Age-Related Macular Degeneration},
  author={Moreno Menghini and Barbara Kloeckener-Gruissem and Johannes Fleischhauer and Malaika M. Kurz-Levin and Florian K. P. Sutter and Wolfgang J Berger and Daniel Barthelmes},
  booktitle={PloS one},
  year={2012}
}
OBJECTIVE Factors influencing the outcome of anti-VEGF treatment in neovascular AMD are still investigated. We analyzed the impact of a loading phase, the significance of an initial response for the long-term and the effect of the CFH polymorphism (p.His402Tyr) on treatment outcome. METHODS Patients treated with ranibizumab for neovascular AMD were analyzed over a period of 24 months by assessing effects of loading phase, initial response and genotype of CFH rs1061170 (c.1204C>T, p.His402Tyr… CONTINUE READING
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