Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells.

@article{Muhammad2011ImpactOI,
  title={Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells.},
  author={Khalid Muhammad and Petra Roll and Thomas Seibold and Stefan Kleinert and Hermann Einsele and Thomas Doerner and H. -P. Tony},
  journal={Annals of the rheumatic diseases},
  year={2011},
  volume={70 8},
  pages={1507-10}
}
OBJECTIVE Interleukin 6 (IL-6) receptor (IL-6R) inhibition by tocilizumab is a novel anti-inflammatory therapy for rheumatoid arthritis (RA) patients. As IL-6 is a late differentiation factor of B cells the authors asked if IL-6R inhibition impacts on the mutational differentiation of human memory B-cell antigen receptors in vivo. METHODS 1733 immunoglobulin receptors (IgR) of single cell sorted preswitch and postswitch memory B cells were prospectively analysed from 11 RA patients under IL… CONTINUE READING

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Immune complexbearing follicular dendritic cells deliver a late antigenic signal that promotes somatic hypermutation

Y Wu, S Sukumar, ME ElShikh
J Immunol • 2008

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