Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder.

@article{Kim2004ImpactOI,
  title={Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder.},
  author={Seonghun Kim and Hee Jae Lee and Ha Gen Koo and Jeong Won Kim and Ji young Song and Mickey K. Kim and Doo hwan Shin and S. O. Young Jin and Mee Suk Hong and Hae Jeong Park and Seo Hyun Yoon and Hang Kyu Park and J Chung},
  journal={Psychiatric genetics},
  year={2004},
  volume={14 3},
  pages={
          165-7
        }
}
OBJECTIVES Variable levels of cytokines were observed in patients with schizophrenia and bipolar disorder, and an especially high level of interleukin-1 (IL-1) was detected in schizophrenia patients. It is known that IL-1 receptor antagonist (IL-1RA) binds to IL-1 receptors and inhibits the receptor binding of IL-1alpha and IL-1beta. METHODS In this study, the association between the variable number of tandem repeats polymorphism of the IL-1RA gene and schizophrenia (n=269) and bipolar… CONTINUE READING
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