Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib.

@article{DesboisMouthon2006ImpactOI,
  title={Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib.},
  author={Christ{\'e}le Desbois-Mouthon and Wulfran Cacheux and Marie-Jos{\'e} Blivet-Van Eggelpo{\"e}l and V{\'e}ronique Barbu and Laetitia Fartoux and Raoul Poupon and Chantal Housset and Olivier Rosmorduc},
  journal={International journal of cancer},
  year={2006},
  volume={119 11},
  pages={
          2557-66
        }
}
Epidermal growth factor receptor (EGFR)- and type 1 insulin-like growth factor receptor (IGF-1R)-dependent pathways are up-regulated in hepatocellular carcinoma (HCC), and cross-talks between both pathways have been described in other systems. Gefitinib, a specific EGFR inhibitor, has shown to reduce significantly, although not completely, HCC formation in rat cirrhotic liver. Here, we investigated whether IGF-1R-dependent pathways may interfere with EGFR signalling in hepatoma cells and, if so… CONTINUE READING
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