Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.

@article{Thobakgale2009ImpactOH,
  title={Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.},
  author={Christina F. Thobakgale and Andrew J. Prendergast and Hayley Crawford and Nompumelelo P. Mkhwanazi and Danni Ramduth and Sharon Reddy and Claudia de Molina and Zenele Mncube and Alasdair J. Leslie and Julia Prado and Fundi Chonco and Wendy Mphatshwe and Gareth Tudor-Williams and Prakash Mohan Jeena and Natasha Blanckenberg and Krista L Dong and Photini Kiepiela and Hoosen Mahomed Coovadia and Thumbi Ndung'u and Bruce D. Walker and Philip J. R. Goulder},
  journal={Journal of virology},
  year={2009},
  volume={83 19},
  pages={10234-44}
}
A broad Gag-specific CD8(+) T-cell response is associated with effective control of adult human immunodeficiency virus (HIV) infection. The association of certain HLA class I molecules, such as HLA-B*57, -B*5801, and -B*8101, with immune control is linked to mutations within Gag epitopes presented by these alleles that allow HIV to evade the immune response but that also reduce viral replicative capacity. Transmission of such viruses containing mutations within Gag epitopes results in lower… CONTINUE READING

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