Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence.

  title={Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence.},
  author={Rebecca P. Payne and Maximilian Muenchhoff and Jaclyn K. Mann and Hannah E. Roberts and Philippa C Matthews and Emily Adland and Allison Jo Hempenstall and Kuan-Hsiang Gary Huang and Mark A Brockman and Zabrina L. Brumme and Marc Sinclair and Toshiyuki Miura and John A. Frater and Myron E Essex and Roger L. Shapiro and Bruce D. Walker and Thumbi Ndung'u and Angela R. McLean and Jonathan M. Carlson and Philip J. R. Goulder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 50},
It is widely believed that epidemics in new hosts diminish in virulence over time, with natural selection favoring pathogens that cause minimal disease. However, a tradeoff frequently exists between high virulence shortening host survival on the one hand but allowing faster transmission on the other. This is the case in HIV infection, where high viral loads increase transmission risk per coital act but reduce host longevity. We here investigate the impact on HIV virulence of HIV adaptation to… CONTINUE READING

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