Impact of HLA alleles and cytokine polymorphisms on inhibitors development in children with severe haemophilia A.

@article{Pergantou2013ImpactOH,
  title={Impact of HLA alleles and cytokine polymorphisms on inhibitors development in children with severe haemophilia A.},
  author={Helen Pergantou and I. Pujol Varela and Olga Moraloglou and Marina Economou and Kleopatra Spanou and Zoey Kapsimali and Nikki Constantinidou and Helen Platokouki},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  year={2013},
  volume={19 5},
  pages={
          706-10
        }
}
Human Leucocyte Antigen (HLA) alleles, cytokine polymorphisms and the type of factor VIII (FVIII) gene mutation are among predisposing factors for inhibitors (inh) development in children with severe haemophilia A (HA). The aim was to investigate the correlations among (i) FVIII gene intron-22 inversion, (ii) HLA alleles and haplotypes and (iii) certain cytokine polymorphisms, with the risk for FVIII inhibitors development in 52 Greek severe HA children, exclusively treated with recombinant… CONTINUE READING

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