Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients.

@article{Lempicki2000ImpactOH,
  title={Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients.},
  author={Richard A. Lempicki and Joseph A Kovacs and Michael W. Baseler and Joseph W. Adelsberger and robert. dewar and Ven Natarajan and Marjorie Bosche and Julia A. Metcalf and Randy A. Stevens and Louise A Lambert and W. Gregory Alvord and Michael A. Polis and Richard T. Davey and D. S. Dimitrov and H. Clifford Lane},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 25},
  pages={13778-83}
}
To evaluate the effects of HIV infection on T cell turnover, we examined levels of DNA synthesis in lymph node and peripheral blood mononuclear cell subsets by using ex vivo labeling with BrdUrd. Compared with healthy controls (n = 67), HIV-infected patients (n = 57) had significant increases in the number and fraction of dividing CD4(+) and CD8(+) T cells. Higher percentages of dividing CD4(+) and CD8(+) T cells were noted in patients with the higher viral burdens. No direct correlation was… CONTINUE READING

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