Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c Levels.

@article{Costantino2017ImpactOG,
  title={Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c Levels.},
  author={Sarah Costantino and Francesco Paneni and Rodolfo Battista and Lorenzo Del Castello and Giuliana Capretti and Sergio Chiandotto and Luigi Tanese and Giustina Russo and Dario Pitocco and Gaetano Antonio Lanza and Massimo Volpe and Thomas F L{\"u}scher and Francesco Cosentino},
  journal={Diabetes},
  year={2017},
  volume={66 9},
  pages={
          2472-2482
        }
}
Intensive glycemic control (IGC) targeting HbA1c fails to show an unequivocal reduction of macrovascular complications in type 2 diabetes (T2D); however, the underlying mechanisms remain elusive. Epigenetic changes are emerging as important mediators of cardiovascular damage and may play a role in this setting. This study investigated whether epigenetic regulation of the adaptor protein p66Shc, a key driver of mitochondrial oxidative stress, contributes to persistent vascular dysfunction in… CONTINUE READING
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