Impact of Gleason Subtype on Prostate Cancer Detection Using Multiparametric Magnetic Resonance Imaging: Correlation with Final Histopathology

@article{Truong2017ImpactOG,
  title={Impact of Gleason Subtype on Prostate Cancer Detection Using Multiparametric Magnetic Resonance Imaging: Correlation with Final Histopathology},
  author={Matthew Truong and Gary M Hollenberg and Eric P Weinberg and Edward Messing and Hiroshi Miyamoto and Thomas Frye},
  journal={The Journal of Urology},
  year={2017},
  volume={198},
  pages={316–321}
}
Purpose: We determined whether Gleason pattern 4 architecture impacts tumor visibility on multiparametric magnetic resonance imaging and correlates with final histopathology. Materials and Methods: A total of 83 tumor foci were identified in 22 radical prostatectomy specimens from patients with a prior negative biopsy who underwent magnetic resonance/ultrasound fusion biopsy followed by radical prostatectomy from January 2015 to July 2016. A genitourinary pathologist rereviewed tumor foci for… Expand
Role of Magnetic Resonance Imaging Targeted Biopsy in Detection of Prostate Cancer Harboring Adverse Pathological Features of Intraductal Carcinoma and Invasive Cribriform Carcinoma
TLDR
Multiparametric magnetic resonance imaging/ultrasound fusion targeted biopsy was associated with significantly increased detection of intraductal/cribriform positive prostate carcinoma compared to systematic sextant biopsy of multiparametric Magnetic resonance imaging negative regions, which supports the role of magnetic Resonance Imaging to enhance the detection of clinically aggressive intradUCTal/ cribRiform positive Prostate carcinoma. Expand
The visibility of prostate cancer concerning underlying histopathological variances: A single-center multiparametric magnetic resonance imaging study.
TLDR
Though it was not reached a statistical significance, clinically significant PCa with the cribriform component and without any intraductal or cribRiform component are more likely to manifests mpMRI invisible foci than the intradUCTal pattern. Expand
Biologic Significance of Magnetic Resonance Imaging Invisibility in Localized Prostate Cancer.
TLDR
Compared with mp MRI-invisible disease, mpMRI-visible tumors are associated with underexpression of cellular organization genes, highlighting the need for biopsy strategies that detect mpMRI -invisible tumors. Expand
Histological differences in cancer cells, stroma, and luminal spaces strongly correlate with in vivo MRI-detectability of prostate cancer
TLDR
Investigation of plausible histopathological factors that affect the detectability of prostate cancers on multiparametric magnetic resonance imaging found changes in cancer cells, stroma, and luminal spaces could be considered one of the best predictors to clinical, in vivo MRI-detectable of prostate cancer. Expand
Spatial density and diversity of architectural histology in prostate cancer: influence on diffusion weighted magnetic resonance imaging.
TLDR
Architectural features influence ADC characteristics of MRI, with more complex tumors having lower ADC values regulated by presence and density of specific morphologies. Expand
Multidimensional analysis of clinicopathological characteristics of false-negative clinically significant prostate cancers on multiparametric MRI of the prostate in Japanese men
TLDR
Tumor detectability of csPC with PI-RADS v2 was limited compared with o-mpMRI criteria in Japanese men, and false-negative lesions on o-MPMRI criteria were characterized as small in size, low risk and low cellularity. Expand
Perineural invasion by prostate cancer on MR/US fusion targeted biopsy is associated with extraprostatic extension and early biochemical recurrence after radical prostatectomy.
TLDR
It is demonstrated that PNI-TB was associated with early biochemical recurrence events within 12 months after prostatectomy and may be useful for PCa risk stratification. Expand
Utility of index lesion volume assessed by multiparametric MRI combined with Gleason grade for assessment of lymph node involvement in patients with high-risk prostate cancer.
TLDR
The combination of biopsy Gleason-grade and mrV may serve as a useful tool to stratify patients according to their risk of nodal metastases in patients with high-risk prostate cancer. Expand
A Comprehensive Analysis of Cribriform Morphology on Magnetic Resonance Imaging/Ultrasound Fusion Biopsy Correlated with Radical Prostatectomy Specimens
TLDR
Although systematic plus targeted biopsy was the most accurate biopsy method to detect cribriform morphology, biopsy sensitivity and specificity remained poor. Expand
Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging and Fusion Guided Targeted Biopsy Evaluated by Transperineal Template Saturation Prostate Biopsy for the Detection and Characterization of Prostate Cancer
TLDR
Multiparametric magnetic resonance imaging alone should not be performed as a triage test due to a substantial number of false‐negative cases with clinically significant prostate cancer and systematic biopsy will remain crucial in the diagnostic pathway of prostate cancer. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Multifocality and prostate cancer detection by multiparametric magnetic resonance imaging: correlation with whole-mount histopathology.
TLDR
It is found that tumor size and grade were important predictors of tumor detection, and although cancer is often multifocal, MRI is often able to detect the worst focus of cancer. Expand
Multiparametric 3T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based molds.
TLDR
Prostate magnetic resonance imaging at 3T allows for the detection of prostate cancer and a multiparametric approach increases the predictive power of magnetic resonance Imaging for diagnosis. Expand
Multiparametric Magnetic Resonance Imaging (MRI) and MRI-Transrectal Ultrasound Fusion Biopsy for Index Tumor Detection: Correlation with Radical Prostatectomy Specimen.
TLDR
Multiparametric magnetic resonance imaging detects the index lesion accurately in 9 of 10 patients; however, the combined biopsy approach, while missing less significant cancer, comes at the cost of detecting more insignificant cancer. Expand
Higher Prostate Cancer Grade Groups Are Detected in Patients Undergoing Multiparametric MRI-targeted Biopsy Compared With Standard Biopsy
TLDR
MRI/US fusion–guided prostate biopsy is equivalent to the standard-of-care 12-core biopsy in terms of cancer detection and superior in detecting higher grade disease. Expand
Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort
TLDR
It is argued that Gleason score assignment by current consensus guidelines are not entirely optimized for clinical use, including active surveillance, and suggested that focal poorly formed gland and cribriform patterns should be in separate prognostic groups, as the latter is associated with worse outcome. Expand
Detection of Clinically Significant Prostate Cancer Using Magnetic Resonance Imaging-Ultrasound Fusion Targeted Biopsy: A Systematic Review.
TLDR
Software-based MRI-US fusion targeted biopsy seems to detect more clinically significant cancers deploying fewer cores than standard biopsy, although further high-quality evidence is needed to change current practice. Expand
Outcome of Gleason 3 + 5 = 8 Prostate Cancer Diagnosed on Needle Biopsy: Prognostic Comparison with Gleason 4 + 4 = 8.
TLDR
Using the most current standards of prostate cancer grading the prognosis is not different in Gleason score 3 + 5 = 8 and 4 + 4 = 8 cancers, which justifies including both in Grade Group 4. Expand
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System
TLDR
The basis for a new grading system was proposed in 2013 by one of the authors and accepted by the World Health Organization for the 2016 edition of Pathology and Genetics: Tumours of the Urinary System and Male Genital Organs. Expand
Extraprostatic Extension Is Extremely Rare for Contemporary Gleason Score 6 Prostate Cancer.
TLDR
In a large prostatectomy cohort, GS6 never had seminal vesicle invasion (0%) and was very rarely (0.28%) associated with extraprostatic extension. Expand
Disease-specific survival of patients with invasive cribriform and intraductal prostate cancer at diagnostic biopsy
TLDR
It is concluded that CR/IDC+ status in prostate cancer biopsies is associated with a worse disease-specific survival, and men with biopsy CR/ IDC− Gleason score 3+4=7 prostate cancer could be candidates for active surveillance, as these patients have similar survival probabilities to those with Gle Mason score 6. Expand
...
1
2
3
...