Impact of GM1 on Membrane-Mediated Aggregation/Oligomerization of β-Amyloid: Unifying View.

@article{Cebecauer2017ImpactOG,
  title={Impact of GM1 on Membrane-Mediated Aggregation/Oligomerization of β-Amyloid: Unifying View.},
  author={Marek Cebecauer and Martin Hof and Mariana Amaro},
  journal={Biophysical journal},
  year={2017},
  volume={113 6},
  pages={1194-1199}
}
In this perspective we summarize current knowledge of the effect of monosialoganglioside GM1 on the membrane-mediated aggregation of the β-amyloid (Aβ) peptide. GM1 has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of Aβ. However, GM1 is known to be neuroprotective against A… CONTINUE READING