Impact of Febuxostat on Renal Function in Gout Patients With Moderate-to-Severe Renal Impairment.

@article{Saag2016ImpactOF,
  title={Impact of Febuxostat on Renal Function in Gout Patients With Moderate-to-Severe Renal Impairment.},
  author={Kenneth G. Saag and Andrew A Whelton and Michael Becker and Patricia A Macdonald and Barbara Hunt and Lhanoo Gunawardhana},
  journal={Arthritis & rheumatology},
  year={2016},
  volume={68 8},
  pages={
          2035-43
        }
}
OBJECTIVE Renal impairment is a risk factor for gout and a barrier to optimal gout management. We undertook this exploratory study to obtain data that have been heretofore limited regarding the safety and efficacy of febuxostat in patients with moderate-to-severe renal impairment (estimated glomerular filtration rate [GFR] 15-50 ml/minute/1.73 m(2) ). METHODS Ninety-six gout patients with moderate-to-severe renal impairment were enrolled in a 12-month multicenter, randomized, double-blind… CONTINUE READING
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