Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.

@article{Deley2010ImpactOE,
  title={Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.},
  author={Marie-C{\'e}cile le Deley and Olivier Delattre and K Sch{\"a}fer and Sue A. Burchill and G. K{\"o}hler and P. C. W. Hogendoorn and Thomas Lion and Christopher Poremba and Julien Marandet and Stelly Ballet and Gaelle Pierron and Samantha C Brownhill and Michaela Nesslb{\"o}ck and Andreas Ranft and Uta Dirksen and Odile Oberlin and Ian J. Lewis and Alan W. Craft and Heribert J{\"u}rgens and Heinrich Kovar},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 12},
  pages={1982-8}
}
PURPOSE EWS-ETS fusion genes are the driving force in Ewing's sarcoma pathogenesis. Because of the variable breakpoint locations in the involved genes, there is heterogeneity in fusion RNA and protein architecture. Since previous retrospective studies suggested prognostic differences among patients expressing different EWS-FLI1 fusion types, the impact of fusion RNA architecture on disease progression and relapse was studied prospectively within the Euro-E.W.I.N.G. 99 clinical trial. PATIENTS… CONTINUE READING

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Results After exclusion of noninformative patients , 565 patients were entered into the prognostic factor analysis comparing type 1 ( n = 296 ) , type 2 ( n = 133 ) , nontype 1/nontype 2 EWS - FLI1 ( n = 91 ) and EWS - ERG fusions ( n = 45 ) .
Results After exclusion of noninformative patients , 565 patients were entered into the prognostic factor analysis comparing type 1 ( n = 296 ) , type 2 ( n = 133 ) , nontype 1/nontype 2 EWS - FLI1 ( n = 91 ) and EWS - ERG fusions ( n = 45 ) .
Results After exclusion of noninformative patients , 565 patients were entered into the prognostic factor analysis comparing type 1 ( n = 296 ) , type 2 ( n = 133 ) , nontype 1/nontype 2 EWS - FLI1 ( n = 91 ) and EWS - ERG fusions ( n = 45 ) .
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