Impact of EGFR mutation analysis in non-small cell lung cancer.

@article{Yamamoto2009ImpactOE,
  title={Impact of EGFR mutation analysis in non-small cell lung cancer.},
  author={Hiromasa Yamamoto and Shinichi Toyooka and Tetsuya Mitsudomi},
  journal={Lung cancer},
  year={2009},
  volume={63 3},
  pages={315-21}
}
The discovery of mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer (NSCLC) accelerated the research of molecular-targeted therapy by EGFR-tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. About 90% of EGFR mutations are clustered in exons 19 (deletion) and 21 (point… CONTINUE READING