Impact of Drug Transporter Studies on Drug Discovery and Development

@article{Mizuno2003ImpactOD,
  title={Impact of Drug Transporter Studies on Drug Discovery and Development},
  author={Naomi Mizuno and Takuro Niwa and Yoshihisa Yotsumoto and Yuichi Sugiyama},
  journal={Pharmacological Reviews},
  year={2003},
  volume={55},
  pages={425 - 461}
}
Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and brain, and play key roles in drug absorption, distribution, and excretion. The information on the functional characteristics of drug transporters provides important information to allow improvements in drug delivery or drug design by targeting specific transporter proteins. In this article we summarize the significant role played by drug transporters in drug disposition, focusing particularly on their… 

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