Impact of Drug-Rich Colloids of Itraconazole and HPMCAS on Membrane Flux in Vitro and Oral Bioavailability in Rats.

Abstract

Improving the oral absorption of compounds with low aqueous solubility is a common challenge that often requires an enabling technology. Frequently, oral absorption can be improved by formulating the compound as an amorphous solid dispersion (ASD). Upon dissolution, an ASD can reach a higher concentration of unbound drug than the crystalline form, and often… (More)
DOI: 10.1021/acs.molpharmaceut.7b00338

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Cite this paper

@article{Stewart2017ImpactOD, title={Impact of Drug-Rich Colloids of Itraconazole and HPMCAS on Membrane Flux in Vitro and Oral Bioavailability in Rats.}, author={Aaron M Stewart and Michael E Grass and Timothy J Brodeur and Aaron K Goodwin and Michael M Morgen and Dwayne T. Friesen and David T. Vodak}, journal={Molecular pharmaceutics}, year={2017}, volume={14 7}, pages={2437-2449} }