Impact of Dextran Sulfate Sodium Load on the Severity of Inflammation in Experimental Colitis

@article{Vowinkel2004ImpactOD,
  title={Impact of Dextran Sulfate Sodium Load on the Severity of Inflammation in Experimental Colitis},
  author={Thorsten Vowinkel and Theodore J. Kalogeris and Mikiji Mori and C. F. Krieglstein and Daniel Neil Granger},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={49},
  pages={556-564}
}
In dextran sulfate sodium (DSS)-induced inflammatory bowel disease in mice the relationship between the amount of ingested DSS and the severity of colitis has not been systematically investigated. We examined whether (1) the severity of colitis is DSS load-dependent, and (2) there is a critical DSS load required to reliably induce colitis. DSS load was calculated as: (drinking volume (ml) × [DSS (g)/100 ml])/body weight (g). A minimum DSS load ≥ 30 mg/g body weight over 7 days resulted in a… CONTINUE READING

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Attenuated mild colonic inflammation Digestive Diseases and Sciences, Vol

  • L Kruidenier, ME van Meeteren, +4 authors HW Verspaget
  • 49, No. 4
  • 2004

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