Impact of DNA ligase IV on the ®delity of end joining in human cells

Abstract

A DNA ligase IV (LIG4)-null human pre-B cell line and human cell lines with hypomorphic mutations in LIG4 are signi®cantly impaired in the frequency and ®delity of end joining using an in vivo plasmid assay. Analysis of the null line demonstrates the existence of an error-prone DNA ligase IV-independent rejoining mechanism in mammalian cells. Analysis of… (More)

Topics

8 Figures and Tables

Cite this paper

@inproceedings{Smith2002ImpactOD, title={Impact of DNA ligase IV on the ®delity of end joining in human cells}, author={Julianne Smith and Enriqueta Riballo and Boris Kysela and C{\'e}line Baldeyron and Kostas Manolis and Christel Masson and Michael R. Lieber and Dora Papadopoulo and Penny A Jeggo}, year={2002} }