Impact of DNA amplification on gene expression patterns in breast cancer.

  title={Impact of DNA amplification on gene expression patterns in breast cancer.},
  author={Elizabeth Hyman and P{\"a}ivikki Kauraniemi and Sampsa Hautaniemi and Maija Wolf and Spyro Mousses and Ester Rozenblum and Markus Ringn{\'e}r and Guido Sauter and Outi Monni and Abdel G. Elkahloun and O. -P. Kallioniemi and Anne Kallioniemi},
  journal={Cancer research},
  volume={62 21},
Genetic changes underlie tumor progression and may lead to cancer-specific expression of critical genes. Over 1100 publications have described the use of comparative genomic hybridization (CGH) to analyze the pattern of copy number alterations in cancer, but very few of the genes affected are known. Here, we performed high-resolution CGH analysis on cDNA microarrays in breast cancer and directly compared copy number and mRNA expression levels of 13,824 genes to quantitate the impact of genomic… CONTINUE READING
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