Impact of Corticosterone Treatment on Spontaneous Seizure Frequency and Epileptiform Activity in Mice with Chronic Epilepsy

@inproceedings{Castro2012ImpactOC,
  title={Impact of Corticosterone Treatment on Spontaneous Seizure Frequency and Epileptiform Activity in Mice with Chronic Epilepsy},
  author={Olagide Wagner de Castro and Victor Rodrigues Santos and Raymund Y. K. Pun and Jessica M. McKlveen and Matthew R Batie and Katherine D. Holland and Margaret A Gardner and Norberto Garcia-Cairasco and James P Herman and Steve C Danzer},
  booktitle={PloS one},
  year={2012}
}
Stress is the most commonly reported precipitating factor for seizures in patients with epilepsy. Despite compelling anecdotal evidence for stress-induced seizures, animal models of the phenomena are sparse and possible mechanisms are unclear. Here, we tested the hypothesis that increased levels of the stress-associated hormone corticosterone (CORT) would increase epileptiform activity and spontaneous seizure frequency in mice rendered epileptic following pilocarpine-induced status epilepticus… CONTINUE READING

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