Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

@article{Pasqua2015ImpactOC,
  title={Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo},
  author={Teresa Pasqua and Sumana Mahata and Gautam Kumar Bandyopadhyay and Angshuman Biswas and G. Alan Perkins and Amiya P. Sinha-Hikim and David S. Goldstein and Lee E. Eiden and Sushil K Mahata},
  journal={Cell and Tissue Research},
  year={2015},
  volume={363},
  pages={693-712}
}
Chromogranin A (CgA) is a prohormone and granulogenic factor in neuroendocrine tissues with a regulated secretory pathway. The impact of CgA depletion on secretory granule formation has been previously demonstrated in cell culture. However, studies linking the structural effects of CgA deficiency with secretory performance and cell metabolism in the adrenomedullary chromaffin cells in vivo have not previously been reported. Adrenomedullary content of the secreted adrenal catecholamines… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 85 REFERENCES

Secretory vesicles membrane area is regulated in tandem with quantal size in chromaffin cells.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2003
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

VMAT-Mediated changes in quantal size and vesicular volume.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2000
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL