Impact of Cellular miRNAs on Circulating miRNA Biomarker Signatures

  title={Impact of Cellular miRNAs on Circulating miRNA Biomarker Signatures},
  author={Radha Duttagupta and Rong Jiang and Jeremy Gollub and Robert C. Getts and Keith W. Jones},
  booktitle={PloS one},
Effective diagnosis and surveillance of complex multi-factorial disorders such as cancer can be improved by screening of easily accessible biomarkers. Highly stable cell free Circulating Nucleic Acids (CNA) present as both RNA and DNA species have been discovered in the blood and plasma of humans. Correlations between tumor-associated genomic/epigenetic/transcriptional changes and alterations in CNA levels are strong predictors of the utility of this biomarker class as promising clinical… CONTINUE READING
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