Impact of Cell Type and Epitope Tagging on Heterologous Expression of G Protein-Coupled Receptor: A Systematic Study on Angiotensin Type II Receptor

Abstract

Despite heterologous expression of epitope-tagged GPCR is widely adopted for functional characterization, there is lacking of systematic analysis of the impact of expression host and epitope tag on GPCR expression. Angiotensin type II (AT2) receptor displays agonist-dependent and -independent activities, coupling to a spectrum of signaling molecules… (More)
DOI: 10.1371/journal.pone.0047016

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@inproceedings{Jiang2012ImpactOC, title={Impact of Cell Type and Epitope Tagging on Heterologous Expression of G Protein-Coupled Receptor: A Systematic Study on Angiotensin Type II Receptor}, author={Lili Jiang and Gladys M. K. Teng and Elaine Y. M. Chan and Shannon Wing Ngor Au and Helen Wise and Susanna Sau-Tuen Lee and Wing-tai Cheung}, booktitle={PloS one}, year={2012} }