Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders

@article{Ehlis2007ImpactOC,
  title={Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders},
  author={Ann-Christine Ehlis and Andreas Reif and Martin J. Herrmann and Klaus-Peter Lesch and Andreas J. Fallgatter},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={162-170}
}
The enzyme catechol-O-methyltransferase (COMT) has attracted increasing interest regarding a genetic disposition towards schizophrenias and as a modulator of prefrontal brain function. A common SNP in the COMT gene causes a Val to Met transition at AA158/AA108 (Val158Met), resulting in reduced COMT activity in Met allele carriers. An impact of COMT genotype on cognition has been well established; however, the exact nature of this influence has yet to be elucidated. The aim of this study was to… CONTINUE READING
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