Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies

@article{Huang2021ImpactOC,
  title={Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies},
  author={Fengying Huang and Chen Zhou and Xiao-yan Zhang and Ye Shen and Hong-wen Zhang and Yong-Qing Wang and Luning Sun},
  journal={Xenobiotica},
  year={2021},
  volume={51},
  pages={1199 - 1206}
}
Abstract Voriconazole (VRC) is a first-line drug for the treatment of invasive fungal infections (IFIs) and an inhibitor of CYP3A activity. The aims of this study are to investigate the influence of related factors on the plasma concentration of voriconazole and the effect of voriconazole on the activity of CYP3A in patients with haematological malignancies. A total of 89 patients received an initial dose of 6 mg/kg followed by 4 mg/kg every 12 h were included in the study. Blood samples were… 

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