Impact of CYP polymorphisms, ethnicity and sex differences in metabolism on dosing strategies: the case of efavirenz

@article{Naidoo2013ImpactOC,
  title={Impact of CYP polymorphisms, ethnicity and sex differences in metabolism on dosing strategies: the case of efavirenz},
  author={Panjasaram Naidoo and Vasudevan V. Chetty and Manoranjenni Chetty},
  journal={European Journal of Clinical Pharmacology},
  year={2013},
  volume={70},
  pages={379-389}
}
PurposeDifferences in drug metabolism due to cytochrome P450 (CYP) polymorphisms may be significant enough to warrant different dosing strategies in carriers of specific cytochrome P450 (CYP) polymorphisms, especially for drugs with a narrow therapeutic index. The impact of such polymorphisms on drug plasma concentrations and the resulting dosing strategies are presented in this review, using the example of efavirenz (EFV).MethodsA structured literature search was performed to extract… CONTINUE READING
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