Impact of CCR5delta32 host genetic background and disease progression on HIV-1 intrahost evolutionary processes: efficient hypothesis testing through hierarchical phylogenetic models.

@article{EdoMatas2011ImpactOC,
  title={Impact of CCR5delta32 host genetic background and disease progression on HIV-1 intrahost evolutionary processes: efficient hypothesis testing through hierarchical phylogenetic models.},
  author={Diana Edo-Matas and Philippe Lemey and Jennifer A. Tom and C{\`e}lia Serna-Bolea and Agnes E van den Blink and Ang{\'e}lique B van 't Wout and Hanneke Schuitemaker and Marc A. Suchard},
  journal={Molecular biology and evolution},
  year={2011},
  volume={28 5},
  pages={1605-16}
}
The interplay between C-C chemokine receptor type 5 (CCR5) host genetic background, disease progression, and intrahost HIV-1 evolutionary dynamics remains unclear because differences in viral evolution between hosts limit the ability to draw conclusions across hosts stratified into clinically relevant populations. Similar inference problems are proliferating across many measurably evolving pathogens for which intrahost sequence samples are readily available. To this end, we propose novel… CONTINUE READING
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CC chemokine

  • A. M. de Roda Husman, H. Blaak, M. Brouwer, H. Schuitemaker
  • 1999
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