Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study

  title={Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study},
  author={Hassan Brim and Pooneh Mokarram and Fakhraddin Naghibalhossaini and Mehdi Saberi-firoozi and Mansour Al-Mandhari and Kamla Al-Mawaly and Rayhaneh Al-Mjeni and Abeer Al-Sayegh and Sandy Raeburn and Edward E. Lee and Francis M. Giardiello and Duane T. Smoot and Alexander Vilkin and Clement Richard Boland and Ajay Kumar Goel and Mitra Hafezi and Mehdi S Nouraie and Hassan Ashktorab},
  journal={Molecular Cancer},
  pages={68 - 68}
We have identified an alternative pathway of tumorigenesis in sporadic colon cancer, involving microsatellite instability due to mismatched repair methylation, which may be driven by mutations in the BRAF gene (V600E). Colorectal cancer (CRC) is the most common cancer in the world, and African Americans show a higher incidence than other populations in the United States. We analyzed sporadic CRCs in Omani (of African origin, N = 61), Iranian (of Caucasian origin, N = 53) and African American (N… CONTINUE READING

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