Impact of Adenosine Receptor Signaling and Metabolism on Pathophysiology in Patients with Chronic Heart Failure

@article{Asakura2007ImpactOA,
  title={Impact of Adenosine Receptor Signaling and Metabolism on Pathophysiology in Patients with Chronic Heart Failure},
  author={Masanori Asakura and Hiroshi Asanuma and Jiyoong Kim and Yulin Liao and Kenji Nakamaru and M. Fujita and Kazuo Komamura and Tadashi Isomura and Hidehiko Furukawa and Hitonobu Tomoike and Masafumi Kitakaze},
  journal={Hypertension Research},
  year={2007},
  volume={30},
  pages={781-787}
}
Adenosine is well known to be a cardioprotective substance in ischemic heart disease. However, the modulation of adenosine receptors and the production and degradation of endogenous adenosine in chronic heart failure (CHF) are not fully understood. We analyzed the gene expression patterns of adenosine-related genes in human failing and nonfailing myocardium using DNA microarray analysis and quantitative real time–polymerase chain reaction (RT-PCR). DNA microarray analysis revealed that the gene… CONTINUE READING
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