Impact of Active Dendrites and Structural Plasticity on the Memory Capacity of Neural Tissue

@article{Poirazi2001ImpactOA,
  title={Impact of Active Dendrites and Structural Plasticity on the Memory Capacity of Neural Tissue},
  author={P. Poirazi and Bartlett W. Mel},
  journal={Neuron},
  year={2001},
  volume={29},
  pages={779-796}
}
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References

SHOWING 1-10 OF 182 REFERENCES
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
TLDR
After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Synaptic integration in an excitable dendritic tree.
TLDR
Results of numerous simulations reveal that dendritic cluster sensitivity is a highly robust phenomenon in dendrites containing a sufficiency of excitatory membrane mechanisms and is only weakly dependent on their detailed spatial distribution, peak conductances, or kinetics.
Redistribution of synaptic efficacy between neocortical pyramidal neurons
TLDR
It is shown that an increase in the synaptic response, induced by pairing action-potential activity in pre- and postsynaptic neurons, was only observed when synaptic input occurred at low frequencies, and arises because of a redistribution of the available synaptic efficacy.
Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons
All-or-none potentiation at CA3-CA1 synapses.
TLDR
Step-like all-or-none transitions from baseline synaptic transmission to potentiated states following protocols for inducing potentiation at putative single CA3-CA1 synaptic connections are characterized, raising the possibility that some forms of synaptic memory may be stored in a digital manner in the brain.
Diversity and dynamics of dendritic signaling.
TLDR
The varied morphology and electrical and chemical properties of dendrites enable a spectrum of local and long-range signaling, defining the input-output relationship of neurons and the rules for induction of synaptic plasticity.
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity…
Dynamic Stochastic Synapses as Computational Units
TLDR
This work considers a simple model for dynamic stochastic synapses that can easily be integrated into common models for networks of integrate-andfire neurons (spiking neurons) and investigates the consequences of the model for computing with individual spikes.
Dynamic synapse: A new concept of neural representation and computation
TLDR
The computational capability of dynamic synapses is demonstrated by performing speech recognition from unprocessed, noisy raw waveforms of words spoken by multiple speakers with a simple neural network consisting of a small number of neurons connected with synapses incorporating dynamically determined probability of release.
Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons.
  • N. Urban, G. Barrionuevo
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
Somatic and dendritic whole-cell recordings are used to show that pyramidal cells in hippocampal area CA3 sum distal and proximal excitatory postsynaptic potentials sublinearly and actively, and that blockade of transient potassium channels linearizes summation.
...
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