Impact of Acid-Reducing Agents on the Pharmacokinetics of Palbociclib, a Weak Base With pH-Dependent Solubility, With Different Food Intake Conditions.

@article{Sun2017ImpactOA,
  title={Impact of Acid-Reducing Agents on the Pharmacokinetics of Palbociclib, a Weak Base With pH-Dependent Solubility, With Different Food Intake Conditions.},
  author={Wan Zhong Sun and Karen J. Klamerus and Lisa M Yuhas and Sylvester Pawlak and Anna Plotka and Melissa T O'Gorman and Leonid Kirkovsky and Maha Kosa and Diane Dan Wang},
  journal={Clinical pharmacology in drug development},
  year={2017},
  volume={6 6},
  pages={
          614-626
        }
}
Palbociclib free base capsule is a weak base drug with highly pH-dependent solubility. In vitro and in vivo studies evaluated the impact of acid-reducing agents on exposure of palbociclib and determined whether the impact, if any, can be mitigated by food. A drug-drug interaction study (study 1) was conducted first under fasted conditions and showed that coadministration of multiple doses of the proton-pump inhibitor rabeprazole substantially reduced palbociclib mean area under the… CONTINUE READING
7
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES