Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study.

@article{Honea2009ImpactOA,
  title={Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study.},
  author={Robyn A. Honea and Eric D Vidoni and A. Harsha and Jeffrey M. Burns},
  journal={Journal of Alzheimer's disease : JAD},
  year={2009},
  volume={18 3},
  pages={553-64}
}
Neuroimaging studies of apolipoprotein E (ApoE4) have implicated its association with brain atrophy in Alzheimer's disease. To date, few studies have used automated morphological analysis techniques to assess ApoE4-related brain structure change in both gray and white matter in nondemented older adults. Nondemented (CDR = 0, n = 53) subjects over 60 had MRI, diffusion tensor imaging, and neurocognitive assessments. We assessed differences in cognition and brain structure associated with ApoE4… CONTINUE READING

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