Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging.

@article{Silva2012ImpactOA,
  title={Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging.},
  author={Ricardo A Pe{\~n}a Silva and Yi Jun Chu and Jordan D. Miller and Ian John Mitchell and Josef M. Penninger and Frank M. Faraci and Donald D. Heistad},
  journal={Stroke},
  year={2012},
  volume={43 12},
  pages={3358-63}
}
BACKGROUND AND PURPOSE Angiotensin II produces oxidative stress and endothelial dysfunction in cerebral arteries, and angiotensin II type I receptors may play a role in longevity and vascular aging. Angiotensin-converting enzyme type 2 (ACE2) converts angiotensin II to angiotensin (1-7) and thus, may protect against effects of angiotensin II. We hypothesized that ACE2 deficiency increases oxidative stress and endothelial dysfunction in cerebral arteries and examined the role of ACE2 in age… CONTINUE READING