Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function

@article{Laechelt2011ImpactOA,
  title={Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function},
  author={Sandra Laechelt and Eleonora Turrini and A Ruehmkorf and Werner Siegmund and Ingolf Cascorbi and Sierk Haenisch},
  journal={The Pharmacogenomics Journal},
  year={2011},
  volume={11},
  pages={25-34}
}
ABCC2 (MRP2) is an important export pump, expressed at tissue barriers. The genetic variants −24C>T, 1249G>A and 3972C>T are leading to inter-individual differences of bioavailability of various endogenous and exogenous compounds. Considering ABCC2 haplotypes, we investigated DNA–protein binding properties, mRNA secondary structure, mRNA stability, protein expression and transport activity in various cell lines and analyzed the bioavailability of talinolol in 24 healthy Caucasian volunteers… CONTINUE READING