Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus.

@article{Dube2015ImpactO,
  title={Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus.},
  author={Vincent Dub{\'e}e and Daria Soroka and M{\'e}lanie A M Cortes and Anne-Laure Lefebvre and Laurent Gutmann and Jean-Emmanuel Hugonnet and Michel Arthur and J. L. Mainardi},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 5},
  pages={2938-41}
}
The production of β-lactamases Bla(Mab) and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from ≥ 256 to 16 to 64 μg/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and… CONTINUE READING
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