Impact and management of breakthrough pain in cancer

@article{Zeppetella2009ImpactAM,
  title={Impact and management of breakthrough pain in cancer},
  author={Giovambattista Zeppetella},
  journal={Current Opinion in Supportive and Palliative Care},
  year={2009},
  volume={3},
  pages={1–6}
}
  • G. Zeppetella
  • Published 1 March 2009
  • Medicine
  • Current Opinion in Supportive and Palliative Care
Purpose of reviewTo outline the impact of breakthrough pain, the evidence for the current management and new treatment options that are becoming available. Recent findingsBreakthrough pain is a transient exacerbation of pain that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain. Despite its self-limiting nature, breakthrough pain can place significant physical, psychological, and… Expand
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TLDR
Evidence that oral transmucosal fentanyl citrate (OTFC) is an effective treatment for breakthrough pain is shown and more trials need to be undertaken. Expand
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Episodic pain is a transient increase in pain intensity over background pain. Episodic pain occurs commonly in cancer patients; it is a heterogeneous phenomenon that is incapacitating, debilitatingExpand
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The intensity of incident pain may be reduced by increasing the opioid dose above that effective for controlling pain at rest, based on experimental bone models showing a hypersensitivity to some innocuous stimuli, such as movement, requiring pre-emptive higher doses of basal opioid medication to reduce the increased pain input. Expand
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TLDR
Diverse interventions were employed to manage these pains, with variable efficacy, and this data clarify the spectrum of breakthrough pains and indicate their importance in cancer pain management. Expand
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TLDR
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TLDR
Oral transmucosal fentanyl citrate (OTFC) recently has been recommended as treatment, but OTFC is not widely available, and alternatives are needed. Expand
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TLDR
This survey explored how acceptable patients view the different routes for the administration of analgesia for breakthrough pain, such as transmucosal, nasal and inhaled, that aim to combine rapid onset of pain relief with convenience. Expand
Breakthrough pain: characteristics and impact in patients with cancer pain
TLDR
The presence of breakthrough pain is a marker of a generally more severe pain syndrome, and is associated with both pain-related functional impairment and psychological distress and the need for further studies of breakthroughPain and more effective therapeutic strategies are suggested. Expand
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TLDR
The study confirmed the applicability of the BPQ to an US veteran population, and that pain management following the AHCPR guidelines is effective for a group of patients with cancer related BP. Expand
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TLDR
Observations suggest that i.v.-M at a dose equivalent to 20% of the basal oral dosage is safe and effective in the majority of patients experiencing pain exacerbation, and can be used at little risk to patients. Expand
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