Immunotoxins against solid tumors

  title={Immunotoxins against solid tumors},
  author={Robert Pirker},
  journal={Journal of Cancer Research and Clinical Oncology},
Antibody-toxin conjugates, termed immunotoxins, are currently being evaluated as potential new anticancer agents. The monoclonal antibodies that recognize antigens on the surface of tumor cells should deliver the toxins or the catalytic subunits of toxins to cancer cells. The catalytically active parts of the immunotoxins have to reach the cell cytoplasm where they inhibit protein synthesis. Immunotoxins against various solid tumors, including breast carcinoma and ovarian carcinoma, have been… CONTINUE READING

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