Immunotoxicity of Perfluorinated Compounds: Recent Developments

  title={Immunotoxicity of Perfluorinated Compounds: Recent Developments},
  author={Jamie C. DeWitt and Margie M. Peden‐Adams and Jennifer M. Keller and Dori R. Germolec},
  journal={Toxicologic Pathology},
  pages={300 - 311}
Perfluorinated compounds (PFCs) are environmentally widespread, persistent, and bioaccumulative chemicals with multiple toxicities reported in experimental models and wildlife, including immunomodulation. The two most commonly detected compounds, which also generally occur in the highest concentrations in environmentally exposed organisms, are perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). PFOA and PFOS have been reported to alter inflammatory responses, production of… 

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