Immunotoxic effects of the color additive caramel color III: immune function studies in rats.

@article{Houben1993ImmunotoxicEO,
  title={Immunotoxic effects of the color additive caramel color III: immune function studies in rats.},
  author={Geert Houben and Andr{\'e} H. Penninks and Willem Seinen and Joseph G. Vos and Henk van Loveren},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1993},
  volume={20 1},
  pages={30-7}
}
Administration of the color additive caramel color III (AC) may cause a reduction in total white blood cell counts in rats due to reduced lymphocyte counts. Beside lymphopenia, several other effects in rat have been described. The effects are caused by the imidazole derivative 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) and occur in rats fed a diet low in vitamin B6. In the present paper, immune function studies on AC and THI with rats fed a diet low, but not deficient in vitamin… CONTINUE READING

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