Immunotolerance against a foreign antigen transgenically expressed in the lens.

  title={Immunotolerance against a foreign antigen transgenically expressed in the lens.},
  author={Joseph C Lai and Atsuki Fukushima and Eric Wawrousek and Mark C. Lobanoff and Puwat Charukamnoetkanok and S J Smith-gill and Barbara P. Vistica and Robert S Lee and Charles E Egwuagu and Scott M. Whitcup and Igal Gery},
  journal={Investigative ophthalmology & visual science},
  volume={39 11},
PURPOSE To extend our knowledge concerning immunotolerance against autologous lens crystallins, transgenic (Tg) mice that express a foreign antigen in their lens were generated, and the immune response against the antigen in these mice was analyzed. METHODS Conventional techniques were used to generate lines of Tg mice that express soluble (S-) or membrane-bound (M-) hen egg lysozyme (HEL) under the control of the alphaA-crystallin promoter. The presence of HEL in various organs was… CONTINUE READING