Immunotherapy with oligomannose-coated liposomes ameliorates allergic symptoms in a murine food allergy model.

@article{Kawakita2012ImmunotherapyWO,
  title={Immunotherapy with oligomannose-coated liposomes ameliorates allergic symptoms in a murine food allergy model.},
  author={Akiko Kawakita and Hisako Shirasaki and Motoko Yasutomi and Shuko Tokuriki and Mitsufumi Mayumi and Hironobu Naiki and Yusei Ohshima},
  journal={Allergy},
  year={2012},
  volume={67 3},
  pages={371-9}
}
BACKGROUND Allergen-specific immunotherapy has been anticipated to be a disease-modifying therapy for food allergies. We previously reported that CD8(+) regulatory T cells may prevent antigen-sensitized mice from developing allergic diarrhea. Because oligomannose-coated liposomes (OML) have been shown to induce MHC class I-restricted CD8(+) T cell responses, we analyzed the adjuvant activities of OML for inducing regulatory CD8(+) T cells and mucosal tolerogenic responses in allergen-sensitized… CONTINUE READING