Immunotherapy with iTreg and nTreg Cells in a Murine Model of Inflammatory Bowel Disease.

@article{Haribhai2016ImmunotherapyWI,
  title={Immunotherapy with iTreg and nTreg Cells in a Murine Model of Inflammatory Bowel Disease.},
  author={Dipica Haribhai and Talal A Chatila and Calvin B. Williams},
  journal={Methods in molecular biology},
  year={2016},
  volume={1422},
  pages={197-211}
}
Regulatory T (Treg) cells that express the transcription factor Foxp3 are essential for maintaining tolerance at mucosal interfaces, where they act by controlling inflammation and promoting epithelial cell homeostasis. There are two major regulatory T-cell subsets, "natural" CD4(+) Treg (nTreg) cells that develop in the thymus and "induced" Treg (iTreg) cells that develop from conventional CD4(+) T (Tconv) cells in the periphery. Dysregulated Treg cell responses are associated with autoimmune… CONTINUE READING