Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

  title={Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine},
  author={Yu-Quan Wei and Qing-ru Wang and Xia Zhao and Li Yang and Ling Tian and You Lu and B. -H. Kang and Chong-jiu Lu and Mei-juan Huang and Yan-yan Lou and Fei Xiao and Qiu-ming He and Jing-mei Shu and Xing-jiang Xie and Yun-qiu Mao and Shong Lei and Feng Luo and Li-qun Zhou and Chong-en Liu and Hao Zhou and Yu Jiang and Feng Peng and Liang-ping Yuan and Qiu Ping Li and Yang Wu and Jiyan Liu},
  journal={Nature Medicine},
The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for… CONTINUE READING
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C - fosinduced growth factor / vascular endothelial growth factor D induces angiogenesis in vivo and in vitro

  • L. Marconcini
  • Proc . Natl . Acad . Sci . USA
  • 1999

Vascular endothelial growth factor ( VEGF ) receptor IIderived peptides inhibit VEGF

  • C. Piossek
  • J . Biol . Chem .
  • 1999

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