Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled vaccine trial.

@article{Straus1997ImmunotherapyOR,
  title={Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled vaccine trial.},
  author={Stephen E. Straus and Anna Wald and Rhonda Kost and Robin McKenzie and Andria G M Langenberg and Patricia Hohman and J A Lekstrom and Elizabeth Cox and Motonobu Nakamura and Rose E. Sekulovich and Allen E. Izu and Conny Dekker and Lawrence Corey},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={176 5},
  pages={1129-34}
}
To determine the safety, immunogenicity, and efficacy of a recombinant herpes simplex virus type 2 glycoprotein D and B vaccine in the treatment of recurrent genital herpes, a randomized, placebo-controlled trial was held at two referral centers. Healthy patients with 4-14 recurrences per year received injections of both glycoproteins in MF59 adjuvant or of MF59 alone at 0, 2, 12, and 14 months. For 18 study months, the rate and number of recurrences, the duration and severity of the first… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

A genetically inactivated immunotherapy of genital herpes

  • Langenberg AGM, RL Burke, SF Adair
  • Lancet
  • 1994

Current developments in herpes simplex virus vaccines

  • PR Krause, SE Straus, RL Burke
  • Semin Virol
  • 1993

The treatment, management and prevention of 23. Burke RL. Current developments in herpes simplex virus vaccines

  • PR Krause, SE Straus
  • Semin Virol 1993;4:187–97
  • 1993

A placebo - controlled trial of vacci - tive in treatment of recurrent herpes simplex virus genitalis in guinea nation with a mixed glycoprotein herpes simplex virus type 1 vaccinepigs

  • SE Straus, B Savarese, M Tigges
  • J Virol
  • 1989

; 141 : 1720 – 7 . recurrence

  • Ho RJY, RL Burke, TC Merigan, CA Benson, ME Turyk, GD Wilbanks
  • J Immunol
  • 1988

Similar Papers

Loading similar papers…