[Immunotherapy of metastatic kidney cancer].


Interleukin 2 (IL2), like Interferon alpha (IFN), is active in metastatic renal cancer, considered to be a chemoresistant cancer. 20 to 30% of objective responses, including 5 to 10% of complete remissions are reported with various protocols of IL2 administration. The considerable toxicity is now well controlled, allowing treatments to be administered in standard wards or even on an outpatient basis by subcutaneous injection. IFN, generally given as long-term treatment, achieved average response rates of between 15 and 20%. Although IL2 and IFN have been granted Product Marketing Authorization in France, the modalities of optimal administration, the place of the combination of IL2-Interferon alpha and the factors predictive of response to treatment still remain unclear.

Cite this paper

@article{Ngrier1993ImmunotherapyOM, title={[Immunotherapy of metastatic kidney cancer].}, author={Sylvie N{\'e}grier and Alain Mercatello and Bel{\'e}n Coronel and Yacine Merrouche and Monique Bret and Jean-Yves Blay and Philippe Thiesse and Michel Clavel and Jean-Fran{\~A}§ois Moskovtchenko and Thierry Philip}, journal={Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie}, year={1993}, volume={3 2}, pages={187-94} }