Immunotherapy of melanoma

  title={Immunotherapy of melanoma},
  author={John B A G Haanen},
  booktitle={EJC supplements : EJC : official journal of EORTC, European Organization for Research and Treatment of Cancer ... [et al.]},
Melanoma is considered one of the immunogenic - if not the most immunogenic - malignancies. This is based on several observations.1.Spontaneous remissions occur occasionally.2.In about 5% of melanomas no primary tumour is found. The genetic aberrations of these tumours closely resemble those of cutaneous melanomas, and therefore are suggestive of spontaneous regressions of the primary tumours.3.Both primary tumours and metastases often have brisk lymphocytic infiltrates, a phenomenon that is… CONTINUE READING